Season both sides of the chicken breasts with Cajun seasoning, smoked paprika, garlic powder, salt, and pepper.
Heat the olive oil in a large skillet over medium-high heat. Add the chicken breasts and cook for 5-7 minutes on each side until golden brown and cooked through (internal temperature should reach 165°F/74°C).
Remove the chicken from the skillet and set aside to rest before slicing into strips.
Cook the Pasta:
While the chicken is cooking, bring a large pot of salted water to a boil. Cook the pasta according to the package instructions, then drain and set aside.
Make the Creamy Sauce:
In the same skillet, melt the butter over medium heat. Add the chopped onion and garlic, sautéing for 2-3 minutes until softened and fragrant.
Pour in the chicken broth and bring to a simmer. Let it cook for 2 minutes to reduce slightly.
Stir in the heavy cream, Parmesan cheese, lemon juice, and red pepper flakes (if using). Let the sauce simmer for 3-4 minutes until it thickens, stirring occasionally.
Season with salt and pepper to taste.
Combine Pasta, Chicken, and Sauce:
Add the cooked pasta to the skillet with the sauce, tossing to coat evenly.
Add the sliced Cajun chicken on top and mix to combine. If the sauce is too thick, you can add a splash of pasta water to reach your desired consistency.
Serve:
Serve the creamy Cajun chicken pasta hot, garnished with fresh parsley and extra Parmesan cheese if desired.
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